Guggulsterone health benefit 

Guggulsterone is a plant sterol present in the resin of the Guggul plant, Commiphora mukul. Guggulsterone is an ingredient in many nutritional supplements.

Health benefit of guggulsterones
Guggulsterone has been used to treat hyperlipidemia, arthritis, and obesity. Although its anti-inflammatory and anti-hyperlipidemic effects have been well documented. guggulsterone may be used to preserve functional beta-cell mass in the pancreas.

How do guggulsterones work?
In humans, guggulsterones act as an antagonist of the farnesoid X receptor. In cells studies with adipocytes, guggulsterones may exert antiobesity effects by inhibiting differentiation of preadipocytes, and by inducing apoptosis and promoting lipolysis of mature adipocytes.

Guggulsterone and prostate cancer
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis.

Molecules of guggulsterone have two stereoisomers, E-guggulsterone and Z-guggulsterone.

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