Bacoside health benefit

Bacoside A is a major constituent isolated from the plant Bacopa monniera Linn. For more information and a Bacopa Monnieri supplement.

Bacoside for liver health
Hepatoprotective effect of Bacoside-A, a major constituent of Bacopa monniera Linn.
Phytomedicine. 2008 Jan 25. Sumathi T, Nongbri A. Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, Tamil Nadu, India.
Bacoside-A was evaluated for its hepatoprotective activity against d-GalN induced liver injury in rats. B-A (10mg/kg of body weight) was administered orally once daily for 21 days and then d-GalN (300mg/kg of body weight) was injected on 21st day after final administration of Bacoside A. Bacoside A reduced the elevated levels of serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (gamma-GT), lactate dehydrogenase (LDH), 5'nucleotidase (5'ND). In addition Bacoside A also significantly restored towards normalization of the decreased levels of Vit-C, and Vit-E induced by d-GalN both in liver and plasma. These results suggest that Bacoside A has hepatoprotective effect against d-GalN induced hepatotxicity in rats.

Bacoside protects brain tissue from cigarette harm
Chronic cigarette smoke exposure enhances oxidative stress, thereby disturbing the tissue defense system and bacoside A protects the brain from the oxidative damage through its antioxidant potential.
 
Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A.
Neuroscience. 2006;138(4):1127-35. Anbarasi K, Kathirvel G, Vani G, Jayaraman G, Shyamala Devi CS. Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
Apoptosis is suggested as a possible contributing factor in the pathogenesis of smoking-induced toxicity. Therefore the present study was designed to investigate the influence of chronic cigarette smoke exposure on apoptosis and the modulatory effect of bacoside A on smoking-induced apoptosis in rat brain. Adult male albino rats of Wistar strain were exposed to cigarette smoke and simultaneously administered with bacoside A  for a period of 12 weeks. Administration of bacoside A prevented expression of hsp70 and neuronal apoptosis during cigarette smoking. We speculate that apoptosis may be responsible for the smoking-induced brain damage and bacoside A can protect the brain from the toxic effects of cigarette smoking.

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Bacoside A is a triterpenoid saponin isolated from the plant Bacopa monniera.