Anthocyanidin health benefit and antioxidant benefit, medical uses

Anthocyanidins are anthocyanins that are not attached to a sugar molecule. Anthocyanins are water-soluble vacuolar flavonoid pigments that appear red to blue. They are synthesized by organisms of the plant kingdom, and have been observed to occur in all tissues of higher plants, providing color in leaves, stems, roots, flowers, and fruits. Scientists have identified hundreds of different anthocyanidins, including pelargonidin, malvidin, delphinidin, peonidin, and cyanidin.

Health benefit
Major sources of anthocyanidins in the American diet are bilberries, blueberries, cherries, raspberries, strawberries, black currants, purple grapes and red wine. Anthocyanidins have a wide range of biological activities including antioxidant, anti-inflammatory, antimicrobial and anti-cancer activities. In addition they display a variety of effects on blood vessels, platelets and lipoproteins able to reduce the risk of coronary heart diseases. You can improve your health by including a wide range of berries in your diet.

Bilberry Supplement Facts:
Serving Size: 1 bilberry capsule
Servings Per Container: 60 capsules

Amount Per Serving:
Bilberry Fruit Standardized Extract - 80 mg
(Vaccinium myrtillus)
Yielding 20 mg anthocyanosides, anthocyanidins
You can purchase Bilberry extract as a supplement and get a healthy amount of anthocyanidins

Bilberry is a dietary supplement used as a vision herb. Bilberry extract contains anthocyanosides, anthocyanins, anthocyanidins, and proanthocyanidins. Bilberry extract, also referred to as blueberry, is a potent extract yielding key bioflavonoids called anthocyanosides or anthocyanins. A controlled extraction process guarantees at least 25% anthocyanosides.

Delphinidin anthocyanidin
Delphinidin, a major biologically active anthocyanidin found in berries, inhibits the vascular endothelial growth factor (VEGF)-induced phosphorylation of VEGF receptor-2 (VEGFR-2) and blocks angiogenesis in vitro and in vivo.

Anthocyanins and anthocyanidins
Anthocyanins, which are O-glycosylated derivatives of anthocyanidins, are responsible for the red, blue and purple coloration of many organs of angiosperms. See also information about a related group of compounds known as proanthocyanidins.

An examination of anthocyanins' and anthocyanidins' affinity for cannabinoid receptors.
A growing body of evidence suggests that anthocyanins and anthocyanidins may possess analgesic properties in addition to neuroprotective and anti-inflammatory activities. These functionalities suggest a role for the cannabinoid receptor (CB) in mediating biological effects. Competitive radioligand binding assays identified cyanidin and delphinidin as ligands with moderate affinity to human CB1. For CB2, similar affinities were achieved by cyanidin, delphinidin (K(i) = 34.3 microM), and peonidin. Inhibition constantswere obtained for pelargonidin, malvidin, cyanidin-3,5-di-O-glucoside, cyanidin-3-O-glucoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside for both CB subtypes. J Med Food. 2009 Dec; Korte G, Dreiseitel A, Schreier P, Oehme A, Locher S, Hajak G, Sand PG. Department of Psychiatry, University of Regensburg, Regensburg, Germany.

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