Abelmoschus moschatus
The antihyperglycemic action of myricetin, purified from the aerial part of Abelmoschus moschatus (Malvaceae), has been investigated in streptozotocin-induced diabetic rats
Improvement of insulin sensitivity in obese Zucker rats by myricetin
extracted from Abelmoschus moschatus.
Planta Med. 2007 August. Department of Pharmacy, Tajen University, Yanpu Shiang,
Ping Tung Shien, Taiwan, ROC.
In an attempt to develop new substances for treating insulin resistance, obese
Zucker rats were employed to screen the effect of myricetin, an active principle
of Abelmoschus moschatus (Malvaceae), on insulin resistance. Myricetin purified
from the aerial portion of the Abelmoschus moschatus plant was administered
intravenously ( I. V.) into animals. These findings indicate that myricetin from
Abelmoschus moschatus herb improves insulin sensitivity through increased
post-receptor insulin signaling mediated by enhancements in IRS-1-associated
PI3-kinase and GLUT 4 activity in muscles of obese Zucker rats. Myricetin might
be used as a model substance for the development of antidiabetic compounds.
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